ISO 18435-3:2015 defines the profiling methodology to use the interoperability templates of ISO 18435‑2. These profiling methods describe the construction and the use of application domain matrix elements (ADMEs), application interaction matrix elements (AIMEs), and an open technical dictionary (OTD) to support the information exchange.

In particular, ISO 18435-3:2015 gives guidance related to profiling the information exchange between two applications by establishing the context, conveyance, and contents defined in ISO 18435‑2.

ISO 18435-3:2015 is intended to be used in conjunction with ISO 18435‑1 and ISO 18435‑2.